15^th World Conference on Cosmetic Dermatology & Skin Diseases September 25-26, 2019 | Lisbon, Portugal

Biography:

Susan Ayton

Susan Ayton is the Founder and Managing Director of Ayton Global Research and inventor and owner of Ayton System Software. She has designed and ran consumer studies for over 250 international clients including large high street chains such as Marks and Spencer, Sainsburys, Superdrug, Wallgreens Boots Alliance, and The Body Shop, as well as global brands such as Oriflame, Temple Spa, Sanctuary and Neal’s Yard Remedies.

Susan has been nominated three times for the Who’s Who of Britain’s Business Elite, has recently won the Mendip Family Business Award, won a place in the International Business category, and has received a further nomination for this category this year.

Carys Smith

Carys Smith has been at the forefront of developments in legislation that affect advertising standards and has put this knowledge to good effect when servicing Ayton Global Research’s international clientele, which now exceeds 250 clients. 

Carys has been with Ayton Global Research for over 7 years and has worked with large conglomerates such as A.S. Watson, Tesco, Sainsburys, Meiyume, and Marks and Spencer as well as luxury brands such as Temple Spa and Oriflame.

Abstract:

Our customers often require guidance with regards to which type of studies to conduct to ensure they are advertising their products in a legally complaint way in all territories they are marketing the products.

This lecture will define what a consumer study is, with reference to global advertising standards. It will also allow the audience to understand the difference between a clinical and a consumer study and the types of claims that can be made by one or the other. Consumer studies include details of any adverse reactions suffered by the population and this lecture covers how this constitutes additional safety data for the PIP/PIF. It focusses on the efficacy claims made about products, including the naming of the products, the effects that they may achieve and how the data is interpreted.

There are time constraints within the R&D process that necessitate the use of a research company with a very broad reach, in terms of overall number and location of volunteers. This is because any well-augmented study will include a highly specific set of inclusion and exclusion criteria, particularly when making claims such as “all skin types”, “for sensitive skin” or” suitable for babies” claims.

The topic of acute or short term and chronic or long-term skin conditions is tantamount to the success of a study and this lecture will cover suitable methods of profiling participants including how to obtain medical approval.

This lecture covers the capture and presentation of adverse reaction data and how dermatologists and toxicologists can access this for the purpose of efficiency and safety.

This lecture will include case studies:

Children and Babies: What considerations should be made with regards to ethics approval?

Bio Oil: Scars are considered to be a medical issue and cosmetics only provide temporary effects. How are the two reconciled?

Adult Eczema: How are adults diagnosed?

Acne: Is it a cosmetic or a medical condition?

Biography:

Dr. Zeenat Meraj completed MBBS from the most premier medical school of Bangladesh in 1983 – Dhaka medical college (DMCH)

She was awarded JICA scholarship and completed her Diploma from Institute of Dermatology, Bangkok in 1997.

She then successfully passed her membership (MCPS) from Bangladesh College of Physicians & Surgeons (BCPS) and went on to get her Fellowship (FCPS) from the same institution.

She has fifteen publications in national and international journals.

Abstract:

Despite the high frequency of disease in general population, as well as women in reproductive years, available information about the effects of ‘Psoriasis on Pregnancy’ and ‘Pregnancy on Psoriasis’ is limited. Most of the changes are more likely to be reported as an improvement. This assumption can be applied more convincingly to plaque type Psoriasis. While exception is represented by generalised Pustular Psoriasis which has been somehow linked to Impetigo Herpetiformis & psoriatic Arthritis.

Recent observations show some association between Psoriasis and Pregnancy complications like pregnancy induced hypertension and trends towards early rupture of membranes, caesarean deliveries, low birth weight babies and preterm delivery. 
Safety profiles of various drugs are incompletely understood. Moisturisers and low to moderate topical steroids or Ultraviolet B phototherapy as the first line. For those women diagnosed with pregnancy discontinuation of Methotrexate three months before conception for both partners is mandatory. Patients receiving agents like Biologics for Psoriatic arthritis can continue till end of second trimester as they do not cross placental barrier.
Lipophilic steroids may also be continued as they too don’t cross placental barrier. For those women whose Psoriasis improves during pregnancy the interruption of therapy can be a reasonable strategy.

The objective of this presentation is to give practical information about clinical, prognostic aspects as well as counselling the couples contemplating pregnancy and management once the patient becomes pregnant.
 

Biography:

Dr. Disha Jaggi is an Aesthetic Physician and Hair transplant surgeon. She has done her fellowship in Aesthetic medicine from the Institute of Laser and Aesthetic, University of Greifswald, Germany. Also she has done her post graduate diploma in Clinical Cosmetology along with certification in Hair transplantation from New Delhi.  She keeps her knowledge updated by attending various International Conferences and has been a part of IMCAS Asia – 2015(BALI), IMCAS Paris in 2016, GAIN MERITA 2018 in Dubai. She has been in the field of aesthetics for past 7 years. She has her own clinic and is also associated with other celebrity chain of clinics in Lucknow, India.

Abstract:

Chemical peeling is a widely used procedure in the management of acne and acne scars. Acne vulgaris is the most common skin disorder in adolescents and young adults. It carries a significant psychological and economic burden to patients and society. Salicylic acid has been used to treat various skin disorders for more than 2,000 years. The ability of salicylic acid to exfoliate the stratum corneum makes it a good agent for peeling. This report entitles the young adult female with acne and was treated with Salycylic acid and glycolic acid peel and the desired outcome was assessed.

Introduction

Acne is a common chronic inflammatory skin disease experienced by most adolescents and young adults and the pathogenesis of acne vulgaris is a multifactorial. The major identified factors that are involved in pathogenesis of active acne lesion formation and scarring are: excess sebum production, follicular epidermal hyper keratinization, the proinflammatory effects of Propionibacterium acnes and other normal skin flora, and immunological reactions.

 The estimated life-time prevalence is ~80%. Patients experience high levels of anxiety, depression, and low self-esteem which lead to impaired quality of life. Therefore, treatment should focus on early intervention & prevention to decrease the physical and esthetic burden of the disease. The treatment of acne is based on a combination of topical therapies, systemic treatments, chemical peels, dermabrasion, laser & oral medication.

 Chemical peeling is one of the most common cosmetic procedures in medical practice and has been used for decades. It is defined as the application of chemical agents, of variable strength, on the skin that results in controlled destruction of the epidermis and dermis. The induced exfoliation is followed by dermal and epidermal regeneration from adjacent epithelium and skin adnexa, which results in improved surface texture and appearance of the skin.

Technique

Superficial peel i.e. salicylic acid peel 30% with combination of oral antibiotics has been started for the patient. Patient was prepared by cleansing and degreasing the whole face by using acetone or 70% alcohol soaked-gauze. Peak results are visible after a series of 3–6 chemical peels depending on the severity of the condition being treated and skin type. Then the whole face was coated with salicylic acid 30% by using cotton-tipped applicator and number of coating ranged from 2-3 application in one sitting, until fine frosting occurred.

At every 2-4 weeks interval, session of peel was done to the patient for around 5 months with 2 sessions of glycolic acid peel are also given in combination for resurfacing of the skin and maintain good texture of skin.

Result

 Salicylic acid peeling used 8 times 2 weeks apart in patient with acne vulgaris and in combination with 2 times 2 weeks apart session of glycolic acid peeling used for resurfacing of skin. Active acne vulgaris included papules and pustules showed significant reduction within 1 month of therapy. After 5 months, remarkable reduction in acne vulgaris and acne scar seen with tightening and whitening of the skin of whole face. Patient was fully satisfied regarding response to therapy. Follow up for three months after peeling showed no relapse in active acne vulgaris and the reduction in scarring was permanent. For maintenance therapy patient was allowed to visit at least once in every 6 months.

Conclusion

SA peel is a safe peeling agent and can be used in different cases of cosmetology procedure e.g. acne vulgaris, melasma, photodamage, freckles, and lentigines. It can be safely used on dark skin type. Equally glycolic acid has also shown to be safe in the treatment of acne even in darker skin types as well as adjunctive therapy for the treatment of acne scars. With this SA also has the added advantage of having a whitening effect, which is favourable darker skin types, as well as those with co-existing hyper pigmentation. Compared to newer technologies for acne and acne scars removal, chemical peeling is affordable and with minimal downtime, and can be performed easily.

Biography:

Abstract:

Biography:

Dr. Zeenat Meraj completed MBBS from the most premier medical school of Bangladesh in 1983 – Dhaka medical college (DMCH)

She was awarded JICA scholarship and completed her Diploma from Institute of Dermatology, Bangkok in 1997.

She then successfully passed her membership (MCPS) from Bangladesh College of Physicians & Surgeons (BCPS) and went on to get her Fellowship (FCPS) from the same institution.

She has fifteen publications in national and international journals.

Abstract:

Abstract: Aging is relentless process that affects all cells, tissues, organs & organisms, diminishing homeostasis and increasing organism vulnerability.

Aging at molecular levels results from increasing entropy that exceeds repair and turnover capacity - a process called ‘Molecular Fidelity’

Aging is a dynamic, biological process of tissue involution and evaluation.

Aging results from both extrinsic and intrinsic factors and may related to ethnic ,variation given innate difference in skin composition due to racial and ethnic background .

We reviewed publications through PubMed search and textbook chapters.

Aging is a multidimensional process including volumetric change, migration of fat pads, absorption of bone, changes in SMAS and extrinsic reflections of environmental factors on skin.

Whatever skin type, signs of aging maybe dark spots, loss of elasticity, loss of volume and rhytides.

Skin of colour has many characteristics that make its aging process unique.

Aging consists of changes of facial rheology eg Volume deflation, Jowl that appears with aging, has been thought in past to represent descent of that part of the jaw line, in reality entire jawline recedes superiorly to expose the jowl. Its volumetric deflation rather than a descent.

Asian skin manifest differently to aging than Caucasians. Increased concentration of melanin in skin of colour makes them more prone to depigmentation – on a positive note more compact dermis makes facial lines and wrinkle less visible.

We need to be aware of differences of biology of Asian skin and clinical approach to aesthetic management of Asian Skin.

Recognizing the unique characteristics of Asian skin allows physicians to optimize cosmetic results and ultimately to a successful rejuvenation of Asian Skin. Aesthetic doctors and Lasers practitioners must be aware of photo damage in Asians and understand the risk of post- inflammatory hyperpigmentation associated with various therapeutic modalities.

Biography:

Ehsan Kamani was born in 1994 in Iran. I am a graduate of the field of optics and laser engineering. I started studying and researching the use of lasers in medicine since 2014. I am mighty in the field of laser. I have an intense internal drive. I am eager to learn medicine and treat people with passion, and the willingness to take a chance, to fail if necessary, and to start the process all over again. I have a passion for research to be able to make life better for people affected by diseases and it is far more important than anything to me. Working in a place nearby cancer department of Shohada University and watching patients affected by cancer complications made me think how I can help these people. I choose University due to the chance that has given to me with its superb research expertise. Research is my passion.

Abstract:

Laser is a technology used in various medical fields.

After the revolution, Penny Celine has been in the medicine of this laser, which has revolutionized medicine

I have studied and studied laser applications in medical sciences, and I have been able to get the right information in this area.

1. Application of laser in drug delivery of cancer tissue: Using a laser and a method for making drugs with nanoparticles, we can use the laser wavelength and appropriate selection of drugs and nanoparticles to target tissues that are used in drug delivery. People with cancer have an important role in minimizing the side effects of chemotherapy
2. Application of Lasers to Improve Endocrine Activity: By using appropriate wavelength lasers and energy, we can influence the process of recovery of the activity of the glands, which is used to improve the thyroid gland, pancreas and saliva.
3. Application of laser in lowering blood pressure: Using low-level lasers can be treated intra articular and topically in the process of reducing blood pressure.
4. Laser application in blood cell proliferation: We can play an important role in laboratory culture using laser light and proper wavelength in the process of white blood cell proliferation, red blood cells, and platelets. This process is important in patients with over-the-counter It will play an important role.
5. Laser application in the treatment of depression: This method will be performed using appropriate light and energy
6. Application of Lasers in Acupuncture: Using a low-power laser and appropriate acupuncture points, we can treat the following illnesses.1 - Obesity 2 - Depression 3 - Impotence - Muscle pain 5 - Paralysis
7. Application of laser in preventing ulcers in chemotherapy patients
8. Application of laser in wound healing of diabetic people
9. Laser application in the treatment of fungus nails with specific color and appropriate laser length
10. Making laser machine for diagnosis as soon as possible

All of these projects will be an important contribution to the recovery of patients and will promote the development of laser medical science. I now need research opportunities and scholarships.

Biography:

Alanoud Hakami is an intern at King Abdulziz Medical City. She graduated in 2019 from King Saud Bin Abdulaziz for Health and sciences with first class honors and a GPA of 9.2. 

Abstract:

Background:

Psoriasis is a chronic inflammatory skin condition of unknown aetiology. It has been presumed that psoriasis is associated with several autoimmune diseases. Data regarding the prevalence of autoimmune diseases in psoriasis is scant. In addition, no study has yet determined the prevalence of autoimmune diseases amongst psoriatic patients in Saudi Arabia.

Objectives:

The aim of this study is to determine the prevalence of autoimmune diseases among psoriatic patients in a tertiary hospital, Riyadh, Saudi Arabia. By recognizing that some psoriatic patients may have strong links to other autoimmune diseases, the diseases can be monitored more efficiently, diagnosed earlier, and treated more effectively.

Methodology:

A cross-sectional study was conducted at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia, where conventional sampling technique was done to include all patients with psoriasis from 2016-2018, and the total sample was 841.

Results:                       

56.4% of our patients were female, and were mostly between the ages of 31-50 years, measuring 37.1%. Only 7.4% of those with psoriasis had a known family history. The majority of our patients did not have a comorbid autoimmune disease. The prevalence of autoimmune diseases in descending order was hypothyroidism 6.8%, alopecia areata 3.6%, atopic dermatitis 2.9%, hyperthyroidism 2.6%, vitiligo 1.9%, rheumatoid arthritis 1.5%, SLE, 0.8%, celiac disease 0.6% and Crohn’s disease 0.5%. Hypothyroidism was the only disease with a statistically significant association p<0.05.  Additionally, a female predominance has been identified among all the autoimmune diseases except crohn’s disease.

Conclusions:

In our study, although multiple autoimmune diseases were present among psoriatic patients, only one autoimmune disease was statistically significant. Our findings suggest possible association between hypothyroidism and psoriasis. Nonetheless, more research is required to develop a deeper understanding of the relationship between psoriasis and autoimmune diseases. 

Biography:

Sheida Naderi-Azad has completed her Bachelor of Science in Microbial and Environmental Pathophysiology from University of British Columbia and is currently an MD Candidate at the University of Toronto Faculty of Medicine. She has an expertise in immunodermatology, with a deep interest in melanoma immunotherapeutics, primary immunodeficiency diseases such as atopic dermatitis, and autoimmune conditions such as psoriasis. She has most recently completed a summer studentship at the Melanoma Clinic, Massachusetts General Hospital. She has had numerous published articles and presentations on melanoma therapeutics, anti-inflammatory conditions and dermatologic comorbidities such as mood disorders.

Abstract:

Statement of the Problem: Advanced melanoma involves metastasis to distant sites and is associated with poor long-term survival (Fisher et al., 2012). Current treatment options for melanoma include interleukin 2, targeted therapy (BRAFi, MEKi) and immunotherapy (CTLA4 antibody, PD1/PDL1 antibody). While targeted therapeutics can successfully block oncogenic signaling with high clinical response, they result in high relapse rates due to acquired resistance. Furthermore, while immunotherapeutics can induce durable responses, they have lower response rates due to immune evasion and suppression of effector function in tumour microenvironment. The purpose of this study is to discuss the potential for combining immunotherapy and targeted therapy with the goal of achieving high response rates with prolonged duration. Methodology & Theoretical Orientation: To obtain these results, various search terms such as immunotherapy and targeted therapy were utilized. Furthermore, the articles were selected based on recency of publication as well as depth of detail regarding the specific immunologic mechanisms by which combination therapies exert their effects. Findings: The results show that potential mechanisms of combinatorial activity of immunotherapy and targeted therapy include increasing antigen presentation, as well as improved lymphocyte homing and function. Yet it is important to note that long-term consequences of combinatorial therapeutics are uncertain, and clinical trials of combinations have resulted in adverse effects such as hepatotoxicity and intestinal perforation. Conclusion & Significance: Altogether, these results indicate a potential combination for BRAF-targeted therapy and immunotherapy in achieving long-term durable responses.

Biography:

Abstract:

One of the latest steps of the psoriatic syndromes is the psoriasis laepraformis.

The AA, unscrupulously tend to assert that it is always better to follow the historiographical path that drives to a determined cure that had been well established and tested since centuries, even if the original ideas were exceptional and results were sometimes  not quite satisfactory.

Aldous Huxley recited “Technological progress has merely provided us with more efficient means for going backwards.” And thus the AA has preferred to go back to investigate the very history of Psoriasis those in very ancient times was confounded with Leprosy.

Leprosy is an ancient, chronic granulomatous disease caused by acid fast bacilli, the Gerhard Armauer Hansen’s bacilli spirilli, affecting all age groups and has no sex predilection. Usually the disease presents with hypo pigmented patches, nodules and plaques with or without loss of sensations and thickening of nerves. Leprosy has a wide range of presentation which can mimic various otherdifferential diagnosis is so wide that one has to exclude wide variety of dermatological diseases before stamping it to be leprosy as stigma is still associated to it. So, since the psoriasis is one of a plentitude of illnesses that does not know therapeutic results at all, notwithstanding ultra-modern and most sophisticated shamans and opinion-makers give false hope and mislead, is resistant to every type of medication, we have observed what ancient physicians employed to combat this malaise in the lands where the illness was endemic.

In most countries where leprosy exists, the term “leprosy” is ignorantly applied to many diseases which cannot properly be regarded as true leprosy. Hence various chronic maladies of the skin occurring in unhealthy persons living in poverty and neglect of cleanliness’ are often confounded with it and the patients, being regarded as “lepers” are treated as outcasts and objects of abhorrence. Lumped together with similar skin disorders that were believed to be contagious, the condition led to confusion with leprosy (and the Old Testament descriptions did not help) and its accompanying social stigma, isolation and shunning. People with psoriasis—thousands in medieval Europe—were forced to warn others of their arrival by ringing a clapper. It has well defined that many simple cutaneous diseases occurring in unhealthy constitutions were often confounded with the true leprosy, so that persons affected with inveterate psoriasis, syphilitic eruptions etc. were often condemned as lepers.

In the past, possible culprits thought to because psoriasis included poor nutrition, microbes, poor hygiene, allergies and malfunctioning internal organs. Numerous pre-19^th-century, ill-conceived treatments were put forth to "cure" skin problems akin to psoriasis. Patients were subjected to remedies and recipes that included cat and dog dung, fresh oil, goose oil and semen, onions mixed with sea salt and urine, and other waste-products.

Ethnobotanically speaking we have discovered in some official documents concerning leprosy in Bristish colonies in the mid-19^th-century that people from Australia and New Guinea used to treat leprosy by applying the juice of the fresh leaves of the extracts from the same leaves of manifold varieties of Myrtaceae.

Amongst those are to number Melaleuca alternifolia, bracteata, cajeputi, lanceolata and minutifolia (and even Gorada, Banbar and Boree, trivial names)  and their extracts are at the basis of Tea tree oil, so famous all over the world.

The AA have prepared a “ceratum” made of beewax, almond oil (as in the ancient recipes) bisabolol, hyaluronic acid and panthenol and a combiné of seven Melaleuca spp (abounding of Cajeputi one) and chloroxylenol (the only xylene that is capable to defeat variable Gram staining bacteria, as Mycobacteria or Hansens’ bacilli spirilli).

7 volunteers (2 Asians, 3 Caucasians, and 2 mulattoes from Haiti) tested the ointment onto their plaques of well ascertained Psoriasis lepraformis (feet, elbows, groin and hands).

Faces did not present manifestations of Ps.Laepraformis.

After 7 days (2 applications pro day) the plaques disappear at all.

In the Asians and Mulattoes the disappearance of the plaques, redness and itch was evident at 4^th and 5^th day.

Biography:

Dr Kacey Hau is a dermatology specialist in private practice. He is the global trainer in thread suspension surgery, botulinum toxin and minimally invasive surgery. He publishes in the literature, poster presentation and book chapters on thread surgery. He is the members of the committees of related advisory boards, expert panels and scientific board.

Abstract:

Introduction: Barb suspension surgery is getting popular as a supplementary choice for facial contouring and reshaping. Compared with formal face lifting, barb suspension provides a safer, minimally invasive and office-based surgical procedure. However, barb suspension surgery do have certain risks due to the invasive nature.

Objective: We would like to evaluate the incidence of adverse events after thread suspension surgery. Through this retrospective analysis, we would like to standardize the possible adverse events to facilitate future reporting and prevention strategies.

Methods: This is a single centre retrospective cohort study on the surgical outcomes. A collection of 200 pairs of thread used in the period of 2017-2019 (two years). The patients were followed up one week, two weeks and four weeks after surgery. The adverse events are stratified according to defined categories. Photos were taken for documentation after patients’ consent.

Results: the incidence of adverse event rate in the first week is 13.5%. It drops in the first 4 weeks, 9.6% at week 2, and 5.5% at week 4. The reported adverse events which persist after 4 weeks(number in brackets) include headache(0), redness(0), swelling and bruising(0), persistent surgical site pain(0), surgical site infection(1), asymmetry(0), palpability of threads(0), early recurrence(0), protrusion and extrusion(5), injury of the local anatomical parts like parotid gland(1), post-inflammatory hyperpigmentation(0), bunching, pleating and dimpling(5).

Discussion and onclusion: Both patient factor, operator factor, material and surgical field can contribute to the incidence. Barb suspension thread surgery is a relatively safe procedure. With careful selection of candidates, well-planned surgery, and respect to the sterility of surgical field and individual anatomical structures, majority of the incidents are avoidable. Clear post-operative care instruction and prompt intervention should issues arise are essential.